Dr. Harleen Quinzel is a new psychologist at Arkham Asylum determined to help patients her colleagues have written off. When she a magnetic criminal able to manipulate everyone but her, Harleen makes a fateful decision leading her and The Joker down a dangerous path that will change Gotham forever.

A truck driver searches across America for the wife she had long assumed was dead. In the course of her search, she will encounter not-quite-human serial murderers, towns literally lost in time, and a conspiracy that goes way beyond one missing woman.

18 years after the Outbreak, the world is starting to re-organize and rebuild, but many different forms of humanity are still struggling to survive in the aftermath. And deep in the places where infected dwell, another descendant lies waiting.